Changes in gene expression in tumors owing to epigenetic modifications and the expression of microRNAs may contribute to the immune microenvironment of tumors. Cytokine expression during T cell development is regulated by epigenetic alteration to both DNA and chromatin. Epigenetic changes to cancer cells make it possible that such changes will influence cytokine profiles that modulate the immune microenvironment.
IMMUNE 3D ™ is designed to evaluate epigenetic factors involved in lymphocyte infiltration. The factors include:
Screening HDAC inhibitors in combination with checkpoint drugs
Ubiquitinase and BTK targeting drug candidates for changes in lymphocyte migration in combination with checkpoints
Signalling pathway evaluations in response to epigenetic targeting