CHECKPOINTS

Checkpoint therapy is the cornerstone of cancer treatments. However, studying the role of checkpoints in the context of the tumor microenvironment requires the right translational systems.

IMMUNE 3D™ is elegantly designed to study patient derived immune and tumor tissue for novel receptor-ligand interactions including the cascading readouts that are a results of targeting checkpoints.

EXAMPLE STUDIES

  • Evaluate the role of targeting PD-1 in Keytruda resistant TIL and tumors – measuring the factors that contribute to resistance of checkpoint blockade.

  • Flow cytometry analysis of changes in checkpoint receptor-ligand expressions

  • Cytokine and chemokine readouts based on blockade of anti-PD1 and anti-PDL1.

CONTACT US TO DISCUSS YOUR STUDY