The tumor immune microenvironment consists of various cells that are important in studying tumor progression. There is a need for better systems to capture the environment, the cells and their interactions with cancer cells. 3D systems bridge the gap between in vitro and in vivo studies. 3D systems can mimic the tumor heterogeneity and enable the study of cell types that contribute to cancer growth and expansion.
Human tumors express a plethora of genetic and epigenetic alterations, which can result in the generation and presentation of neoantigens. These tumor-associated antigens allow the immune system to recognize the tumors and can result in the recruitment of immune cells within the tumor microenvironment. While initially effective, tumors develop multiple mechanisms to evade and suppress this response. These mechanisms include the production of soluble factors such as suppressive cytokines amino acid catabolizing enzymes, as well as express immune checkpoints, which are typically used to stop immune responses in order to avoid inflammation. In order to reverse tumor-mediated immune suppression, significant progress has been made in the development of checkpoint inhibitor therapy and it has revolutionized current cancer treatment strategies.
IMMUNE3D ™ is designed to capture the key components of the human tumor immune microenvironment and can be adapted to study various mechanisms that are essential to better understanding and identifying IO drug candidates.
Several mechanisms and factors contribute to infiltration, resistance, immunosuppression and antigen presentation. We have established modules that can be customized to include multiple cell types and readouts.