We aim to develop 3D platforms that capture the immune context and disease environments to better understand drug profiles, identify biomarkers and novel targets. Our vision is to be the leader in 3D culture platforms that can be applied across the translational spectrum.
Three-dimensional (3D) cell cultures have gained wide acceptance as platforms that mimic the in vivo physiology. 3D cell cultures are now an established “tool” in early preclinical drug development and in discovery efforts. With immunology playing a central role in diseases such as cancer and autoimmunity, it is important to shift the focus of 3D platforms towards the evaluation of immune cells in relation to diseased tissues and cells.
The immune system plays a role in many major diseases by protecting us against infectious agents and malignant cells or by causing disease in the case of autoimmunity. To build physiologically relevant 3D platforms begins with an in-depth understanding of disease pathogenesis and the factors that contribute to disease biology. This understanding coupled with technological advancements enables us to develop meaningful 3D platforms
T cell migration allows for the detection of antigen at the surface of antigen-presenting cells and for interactions with other immune cells. T cell migration is governed by mechanisms that are optimized for both the activation stage of the cell and for environment-specific cues. A number of factors including chemokines, stromal factors and matrix metalloproteinases have been shown to influence the infiltration of T cells in the TME.